Neuromarkers for Chronic Fatigue Syndrome

This study aims to explore differences in brain function during sleep and alertness among three groups: people with normal sleep patterns but daytime fatigue (chronic fatigue syndrome), those with insomnia, and healthy sleepers.

Study Purpose/Description

This study explores differences in brain function during sleep and alertness in people with chronic fatigue syndrome (CFS) who experience unrefreshing/non-restorative sleep, compared to those with non-restorative sleep who do not have CFS. This study will also be looking at individuals with insomnia and healthy sleepers. The goal is to better understand the mechanisms behind unrefreshing sleep and daytime fatigue with CFS, insomnia and compare them to participants without these conditions.

What’s Involved

This study will involve a two-hour face to face screening visit and one overnight High-Density EEG sleep study. During the screening visit you will be asked to complete electronic questionnaires that will help assess your eligibility and given a portable device to wear to measure your blood oxygen levels to detect any risk of sleep disorders (i.e., obstructive sleep apnoea).

If you do not show any signs of sleep disorders, you will be contacted by a member of the research team to participate in the overnight research sleep study, this time using high-density EEG (HD-EEG) which you will have a chance to try on during the screening visit.

The HD-EEG visit will also be accompanied by computerised tests and biological samples. After this visit, a time will be arranged for you to attend an appointment at the Brain and Mind Centre in Camperdown to undergo magnetic resonance imaging (MRI).

The research team will provide taxi vouchers for transport to and from the laboratory with a maximum cost of $250. You can also use our free and secure parking under the Woolcock building and we will offer to reimburse public transport costs. In addition, you will receive $100 upon completion of the study.

Screening Survey Link

If you think you might be eligible and interested you can visit the study screening website: https://nrs.wappsystem.com.au/?/home.

Recruitment criteria

You may be eligible to participate in this study if you:

  • Are aged 18-65 years old
  • Have regular sleep and waking hours
  • Fit into one of these three groups:
    • Healthy sleeper
    • Diagnosed with non-restorative sleep
    • Diagnosed with insomnia disorder
  • Are able and willing to travel to the Woolcock Institute in Macquarie Park, NSW.

You will not be able to participate if you:

  • do not speak English
  • are a shift worker
  • have been diagnosed with a sleep disorder (e.g., sleep apnoea, restless leg syndrome)
  • have a severe mental health disorder/s (e.g., schizophrenia, bipolar disorder)
  • are currently taking more than one type of medication
  • will not be able to have an MRI scan due to claustrophobia, pregnancy or metal fragments/foreign bodies in your body
  • consume more than 2 standard alcohol drinks daily

Benefits

Participants will receive $100 upon completion of the study.

Study sponsor / funder

Research team contacts

Research Team

Register your interest


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